IIT Mandi shows possible role of signal peptide aggregation on Alzheimer’s disease

IIT Mandi researchers have shown the possible role of signal peptide aggregation on Alzheimer’s disease.

A research team from the Indian Institute of Technology Mandi led by Dr. Rajanish Giri, Associate Professor, School of Basic Sciences, IIT Mandi, has discovered an important biomolecular mechanism for the formation of protein clusters/aggregates that are often seen in Alzheimer’s disease. They have shown that signal peptides of the Amyloid Precursor Protein (APP) can co-aggregate with Amyloid beta-peptide (A42). This A42, known for the pathogenesis of Alzheimer’s disease, is a most common form of dementia that slowly destroys memory and other important mental functions.