Prisco's NFL Week 1 odds, picks: Mac Jones wins Patriots debut, Bills edge Steelers, Sam Darnold gets revenge

Prisco reveals his Week 1 NFL picks, including why the Cowboys will keep it close in Tampa

Words of warning to all those picking Week 1 NFL games: Expect the unexpected. Even with three preseason games this year, compared to none last season because of COVID-19, it's always tough to try and get a gauge on how good teams are in Week 1. That's why picking games is a challenge early in the season. Some teams played starters in the preseason, while others did not. Some showed stuff, while most did not. Evaluations are always tough coming out of the preseason.