Floyd Mayweather vs. Manny Pacquiao set for 'Fight of the Century' rematch at Sphere in Las Vegas

Mayweather and Pacquiao are set to fight for a second time after 'Money' won the first meeting in 2015

Manny Pacquiao and Floyd Mayweather are set to run back one of the biggest fights in boxing history. Mayweather and Pacquiao will rematch in a Sept. 19 clash from The Sphere in Las Vegas, as announced by Netflix, with the streaming service set to air the event.

The first meeting between Pacquiao and Mayweather took years of negotiation to come together, as both fighters were on top of the boxing world. The fight eventually happened in May 2015. Mayweather won the fight by clear unanimous decision, with the fight reportedly drawing more than 4.5 million pay-per-view buys, making it a massive success, though the fight itself disappointed many due to a general lack of action.

Negotiations for the first meeting began in early 2010, though those plans fell apart when the two sides could not come to an agreement on drug testing for the fight.

Drug testing would continue to be a sticking point as negotiations would continue as time passed. Between the type of drug testing, with Mayweather wanting "Olympic-style" testing, or timing, with Pacquiao refusing testing that went beyond 14 days prior to the bout, testing remained an ongoing sticking point as the negotiations dragged on for years.

Over the past few years, the idea of a rematch has popped up repeatedly, though it never seemed to gain much momentum until recent months, when interest was ignited once again.