Fiery Bulgaria bus crash kills at least 45 people, including children

 At least 45 people, including 12 children, died as a bus carrying mostly North Macedonian tourists crashed in flames on a highway in western Bulgaria hours before daybreak on Tuesday, officials said.

Seven people who leapt from the burning bus were rushed to hospital in Sofia and were in stable conditions, hospital staff said. Bulgaria's interior ministry said 45 people died, making it the most deadly bus accident in the Balkan country's history.

Interior Minister Boyko Rashkov said bodies were "clustered inside and are burnt to ash."

"The picture is terrifying, terrifying. I have never seen anything like that before," he told reporters at the site.

The cause of the accident was unclear but the bus appeared to have hit a highway barrier either before or after it caught fire, Bulgarian officials said.

The accident happened on Struma highway about 45 kilometres west of Sofia around 2:00 a.m. local time, Bulgarian officials said. The coach party was returning to Skopje from a weekend holiday trip to Istanbul, a trip of about 800 kilometres.

Television footage showed the bus charred and gutted by fire in the middle of the highway, which was wet from rain overnight.

"We have an enormous tragedy here," Bulgarian interim Prime Minister Stefan Yanev told reporters.

North Macedonian Prime Minister Zoran Zaev said he had spoken to one of the survivors who told him the passengers were sleeping when they were woken by the sound of an explosion.

"I am terrified. This is such a huge tragedy," he told private television channel BTV.

Bulgarian investigative service chief Borislav Sarafov said four buses from a North Macedonian travel agency had entered Bulgaria late on Monday from Turkey.

"Human mistake by the driver or a technical malfunction are the two initial versions for the accident," he said.