Ellen Pompeo Leaves the Hospital

For 20 years, the star of “Grey’s Anatomy” has rarely worked elsewhere. For a new Hulu series, about an adoption gone very wrong, she changes out of her scrubs.

At the Los Angeles County Museum of Art, Ellen Pompeo stood in a room of Picassos, mostly in the Cubist style. She paused in front of a portrait of a woman in a blue dress. The eyes were at strange angles, the mouth tucked to one side. The nose was somehow everywhere.

Pompeo, 55, tilted her head, trying to resolve the features into one coherent face. Then she gave up.

“There’s three sides to every story,” she said. “Or six sides. Or nine. That is why art keeps us alive: Because everybody gets to see things their way, to make sense of them.”

For a long time Pompeo’s Hollywood story has been a simple one, the perspective fixed. She modeled sporadically throughout her 20s, had a starring role in one film and smaller parts in others. Since 2005 she has led the most popular medical show of the post-“ER” era, ABC’s “Grey’s Anatomy.” Pompeo plays the surgeon Meredith Grey, a sturdy moral center in a fervid, ethically uncertain world.

In the intervening years, barring a handful of crossover episodes on “Station 19,” a “Grey’s” sister show, Pompeo has amassed few other credits — a “Doc McStuffins” voice-over here, an appearance in a Taylor Swift video there. It wasn’t that she lacked artistic ambitions, but the “Grey’s” schedule was punishing and spending her brief hiatus making movies felt irresponsible, especially after she became a mother. (She and her husband, Chris Ivery, a music producer, have three children.)

In 2022, she renegotiated her “Grey’s” contract, reducing the number of episodes she would appear in. This allowed for her first new substantive role in nearly two decades, as a flawed suburban supermom named Kristine Barnett, in “Good American Family,” a limited series that premieres on Hulu on Wednesday.