Vaccine Mix-and-Match Gives Similar Protection As Booster Shot: Study
NDTV
The US government-sponsored trial is the first major US study to compare the effects of using different vaccines as boosters from the initial shot or shots.
Mixing Covid vaccines produces as much or more antibodies as using the same shot as a booster, according to preliminary results of a widely awaited US government-sponsored trial.
The trial is the first major US study to compare the effects of using different vaccines as boosters from the initial shot or shots. The complicated, 9-arm trial involved over 450 people and measured the effects from giving a booster shot of the Moderna Inc, Pfizer Inc.-BioNTech SE or Johnson & Johnson vaccines to those who had originally gotten a different vaccine.
Overall, the results found that mixing-and-matching resulted in comparable or higher levels of neutralizing antibodies compared to same-vaccine boosting, the researchers said in the preprint posted on medRxiv.org. Rates of adverse events were similar across all the different booster groups, the study found.
"These data suggest that if a vaccine is approved or authorized as a booster, an immune response will be generated regardless of the primary Covid-19 vaccination regimen," the researchers said in their conclusion.
