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NFL Week 2 odds, predictions, expert picks: Will Chiefs get revenge vs. Eagles? Can Vikings start 2-0?

NFL Week 2 odds, predictions, expert picks: Will Chiefs get revenge vs. Eagles? Can Vikings start 2-0?

CBSN
Friday, September 12, 2025 08:43:17 PM UTC

CBS Sports and SportsLine break down every single Week 2 matchup

Another week, another round of must-see matchups across the NFL. One week after some stunning developments, like Daniel Jones torching the Miami Dolphins and Justin Herbert stepping up in crunch time to best the Kansas City Chiefs, we've got another slate full of intriguing action in Week 2.

As we'll do every week throughout the season, we've collected all of the best picks and gambling content from CBS Sports and SportsLine and put them in one place. That way, you can get picks against the spread from our CBS Sports experts as well as additional feature content for each game, including plays from top SportsLine experts and the SportsLine Projection Model, best bets from our staff, survivor picks and more. Ready? Let's jump in.

Bet NFL Week 2 games and NFL odds at DraftKings, where new users get $200 in bonus bets and over $200 off NFL Sunday Ticket. Click here to get started:

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