IIT Kanpur team identifies a novel target to treat prostate cancer
The Hindu
In mice, BET inhibitors used alone or in combination with anti-androgen drugs was found effective
Researchers at the Indian Institute of Technology (IIT), Kanpur, have discovered that a particular gene (DLX1) which plays an important role in the development of jaws, skeleton, and interneurons in the brain has an important role to play in the growth and development of prostate cancer.
The DLX1 protein is found at elevated levels in prostate cancer patients, the reason why the DLX1 protein has been used as a urine-based biomarker. Now the team of researchers led by Dr. Bushra Ateeq, Professor at the Department of Biological Sciences and Bioengineering, IIT Kanpur has found that the DLX1 protein, which is expressed at higher levels in the prostate cancer cells, has a huge role in the growth and development of the tumour and the spread of the cancer to other organs in the body (metastasis).
Using small molecules as inhibitors, the researchers have shown in mice a new therapeutic strategy to treat people with DLX1-positive prostate cancer.
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