Everything you need to know about Ayatollah Ali Khamenei, supreme leader of Iran

Ayatollah Ali Khamenei's grip on power faces unprecedented challenges after Israel's strike on Iran's nuclear facilities, with his regional allies weakened and his inner circle compromised.

Ruth Marks Eglash is a veteran journalist based in Jerusalem, Israel. She reports and covers the Middle East and Europe. Originally from the U.K, she has also freelanced for numerous news outlets. Ruth can be followed on Twitter @reglash

Over decades of rule, Khamenei has built an impenetrable circle around him both inside and outside of Iran. Now, with Israel taking out some of his closest aides and senior security figures, as well as significantly weakening its militant Islamic allies across the region, the supreme leader is beginning to look increasingly isolated.