Accelerated aging linked to cancer risk in younger adults, research shows

Researchers looking for clues to why some types of cancer are on the rise in younger adults say they’ve found an interesting lead — a connection to accelerated biological aging.

Researchers looking for clues about why some types of cancer are on the rise in younger adults say they’ve found an interesting lead: a connection to accelerated biological aging. Aging is the major risk for many types of cancer, meaning the older you get, the more likely you are to be diagnosed. And increasingly, experts recognize that age is more than just the number of candles on a birthday cake. It’s also the wear and tear on the body, caused by lifestyle, stress and genetics, which is sometimes referred to as a person’s biological age. “We all know cancer is an aging disease. However, it is really coming to a younger population. So whether we can use the well-developed concept of biological aging to apply that to the younger generation is a really untouched area,” said Dr. Yin Cao, an associate professor of surgery at the Washington University School of Medicine in St. Louis and senior author of the new research, which was presented Sunday at the American Association of Cancer Research’s annual conference in San Diego. Cao and her team looked at the medical records of 148,724 people ages 37 to 54 who are participants in a large data registry called the UK Biobank. They homed in on nine blood-based markers that have been shown to correlate with biological age: These nine values were then plugged into an algorithm called PhenoAge that was used to calculate each person’s biological age. The researchers determined accelerated aging by comparing people’s biological ages with their chronological ages.