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新突破!中国科学家诱导出“最年轻”人类全能干细胞

新突破!中国科学家诱导出“最年轻”人类全能干细胞

China Daily
Wednesday, March 23, 2022 06:37:27 PM UTC

近日,来自中国科学院、深圳华大生命科学研究院等研究团队,通过体细胞诱导培养出了类似受精卵发育3天状态的人类全能干细胞。这是继科学家成功诱导出人类多能干细胞后,再生医学领域的又一重大突破。

An international team led by Chinese scientists has successfully produced the youngest human cells in vitro, which may pave the way for advances in organ regeneration.

一个由中国科学家领衔的国际研究团队成功在体外培养出全球“最年轻”的人类细胞,该成果将助力实现未来人体器官的体外再生。

 

The study published Tuesday in the journal Nature announced the discovery of a rapid, controllable method to convert stem cells into bona fide 8-cell embryo-like cells, without relying on genetic engineering.

研究者们开发了一种非转基因、快速且可控的方法,能够将人的干细胞转化为全能性的8细胞期胚胎样细胞。相关研究成果于北京时间3月22日凌晨在国际学术期刊《自然》(Nature)上发表。

 

【知识点】

2012年,诺贝尔生理学或医学奖(Nobel Prize in Physiology or Medicine)授予了日本科学家山中伸弥(Shinya Yamanaka)和英国发育生物学家(developmental biologist)约翰·格登(John Gurdon)。前者是诱导多功能干细胞(induced pluripotent stem cells, iPS)技术开发者之一,后者则在细胞核移植(nuclear transplantation)方面进行了开创性的研究。这些研究免除了科学家使用人体胚胎(human embryos)提取干细胞的伦理道德制约(ethical constraints),从而使与干细胞(stem cells)有关的疾病研究能更进一步。与此同时,将成熟的体细胞重编程(reprogramming),“倒推”到更加多能(pluripotent)甚至全能(totipotent)的状态,这仍然是科学界的长期追求。

 

A team of researchers from China, Britain and Bangladesh converted pluripotent stem cells, or an "adult" version of early embryonic cells, back to a more "juvenile" version of cells with developmental potential, tantamount to fertilized eggs in their Day 3 developmental stage.

Read full story on China Daily
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